Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes

Gene silencing by targeted DNA methylation has potential applications in basic research and therapy. To establish targeted methylation in human cell lines, the catalytic domains (CDs) of mouse Dnmt3a and Dnmt3b DNA methyltransferases (MTases) were fused to different DNA binding domains (DBD) of GAL4...

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Detalles Bibliográficos
Autores principales: Li, Fuyang, Papworth, Monika, Minczuk, Michal, Rohde, Christian, Zhang, Yingying, Ragozin, Sergei, Jeltsch, Albert
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761428/
https://www.ncbi.nlm.nih.gov/pubmed/17151075
http://dx.doi.org/10.1093/nar/gkl1035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761428/
https://www.ncbi.nlm.nih.gov/pubmed/17151075
http://dx.doi.org/10.1093/nar/gkl1035

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