Cargando…
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
Gene silencing by targeted DNA methylation has potential applications in basic research and therapy. To establish targeted methylation in human cell lines, the catalytic domains (CDs) of mouse Dnmt3a and Dnmt3b DNA methyltransferases (MTases) were fused to different DNA binding domains (DBD) of GAL4...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761428/ https://www.ncbi.nlm.nih.gov/pubmed/17151075 http://dx.doi.org/10.1093/nar/gkl1035 |