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Restricted epithelial proliferation by lacritin via PKCα-dependent NFAT and mTOR pathways

Renewal of nongermative epithelia is poorly understood. The novel mitogen “lacritin” is apically secreted by several nongermative epithelia. We tested 17 different cell types and discovered that lacritin is preferentially mitogenic or prosecretory for those types that normally contact lacritin durin...

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Detalles Bibliográficos
Autores principales: Wang, Jiahu, Wang, Ningning, Xie, Jinling, Walton, Staci C., McKown, Robert L., Raab, Ronald W., Ma, Peisong, Beck, Shannon L., Coffman, George L., Hussaini, Isa M., Laurie, Gordon W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1761701/
https://www.ncbi.nlm.nih.gov/pubmed/16923831
http://dx.doi.org/10.1083/jcb.200605140