Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling

BACKGROUND: Niemann-Pick Type C (NPC) disease is a neurodegenerative disease that is characterized by the accumulation of cholesterol and glycosphingolipids in the late endocytic pathway. The majority of NPC cases are due to mutations in the NPC1 gene. The precise function of this gene is not yet kn...

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Detalles Bibliográficos
Autores principales: Reddy, Jonathan V., Ganley, Ian G., Pfeffer, Suzanne R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762405/
https://www.ncbi.nlm.nih.gov/pubmed/17183645
http://dx.doi.org/10.1371/journal.pone.0000019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762405/
https://www.ncbi.nlm.nih.gov/pubmed/17183645
http://dx.doi.org/10.1371/journal.pone.0000019

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