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Clues to Neuro-Degeneration in Niemann-Pick Type C Disease from Global Gene Expression Profiling
BACKGROUND: Niemann-Pick Type C (NPC) disease is a neurodegenerative disease that is characterized by the accumulation of cholesterol and glycosphingolipids in the late endocytic pathway. The majority of NPC cases are due to mutations in the NPC1 gene. The precise function of this gene is not yet kn...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762405/ https://www.ncbi.nlm.nih.gov/pubmed/17183645 http://dx.doi.org/10.1371/journal.pone.0000019 |