The Interplay between PolyQ and Protein Context Delays Aggregation by Forming a Reservoir of Protofibrils

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the expansion of CAG codon repeats, which code for polyQ in the corresponding gene products. These diseases are associated with the presence of amyloid-like protein aggregates, induced by polyQ expansion. It has been...

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Detalles Bibliográficos
Autores principales: Bulone, Donatella, Masino, Laura, Thomas, David J., San Biagio, Pier Luigi, Pastore, Annalisa
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762411/
https://www.ncbi.nlm.nih.gov/pubmed/17205115
http://dx.doi.org/10.1371/journal.pone.0000111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762411/
https://www.ncbi.nlm.nih.gov/pubmed/17205115
http://dx.doi.org/10.1371/journal.pone.0000111

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