A Critical Role for FBXW8 and MAPK in Cyclin D1 Degradation and Cancer Cell Proliferation

Cyclin D1 regulates G1 progression. Its transcriptional regulation is well understood. However, the mechanism underlying cyclin D1 ubiquitination and its subsequent degradation is not yet clear. We report that cyclin D1 undergoes increased degradation in the cytoplasm during S phase in a variety of...

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Detalles Bibliográficos
Autores principales: Okabe, Hiroshi, Lee, Sang-Hyun, Phuchareon, Janyaporn, Albertson, Donna G., McCormick, Frank, Tetsu, Osamu
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762433/
https://www.ncbi.nlm.nih.gov/pubmed/17205132
http://dx.doi.org/10.1371/journal.pone.0000128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762433/
https://www.ncbi.nlm.nih.gov/pubmed/17205132
http://dx.doi.org/10.1371/journal.pone.0000128

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