Selective Loss of TGFβ Smad-Dependent Signalling Prevents Cell Cycle Arrest and Promotes Invasion in Oesophageal Adenocarcinoma Cell Lines

In cancer, Transforming Growth Factor β (TGFβ) increases proliferation and promotes invasion via selective loss of signalling pathways. Oesophageal adenocarcinoma arises from Barrett's oesophagus, progresses rapidly and is usually fatal. The contribution of perturbed TGFβ signalling in the prom...

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Detalles Bibliográficos
Autores principales: Onwuegbusi, Benjamin A., Rees, Jonathan R.E., Lao-Sirieix, Pierre, Fitzgerald, Rebecca C.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766472/
https://www.ncbi.nlm.nih.gov/pubmed/17264880
http://dx.doi.org/10.1371/journal.pone.0000177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766472/
https://www.ncbi.nlm.nih.gov/pubmed/17264880
http://dx.doi.org/10.1371/journal.pone.0000177

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