Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study

We previously established a role for the second messenger ceramide in protein kinase R (PKR)-mediated articular cartilage degradation. Ceramide is known to play a dual role in collagen gene regulation, with the effect of ceramide on collagen promoter activity being dependent on its concentration. Tr...

Descripción completa

Detalles Bibliográficos
Autores principales: Gilbert, Sophie J, Blain, Emma J, Jones, Pamela, Duance, Victor C, Mason, Deborah J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779424/
https://www.ncbi.nlm.nih.gov/pubmed/16696862
http://dx.doi.org/10.1186/ar1961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779424/
https://www.ncbi.nlm.nih.gov/pubmed/16696862
http://dx.doi.org/10.1186/ar1961

Ejemplares similares