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Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study

We previously established a role for the second messenger ceramide in protein kinase R (PKR)-mediated articular cartilage degradation. Ceramide is known to play a dual role in collagen gene regulation, with the effect of ceramide on collagen promoter activity being dependent on its concentration. Tr...

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Detalles Bibliográficos
Autores principales:	Gilbert, Sophie J, Blain, Emma J, Jones, Pamela, Duance, Victor C, Mason, Deborah J
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2006
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779424/ https://www.ncbi.nlm.nih.gov/pubmed/16696862 http://dx.doi.org/10.1186/ar1961

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