Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis

Excess proteolysis of the extracellular matrix (ECM) of articular cartilage is a key characteristic of arthritis. The main enzymes involved belong to the metalloproteinase family, specifically the matrix metalloproteinases (MMPs) and a group of proteinases with a disintegrin and metalloproteinase do...

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Detalles Bibliográficos
Autores principales: Milner, Jennifer M, Rowan, Andrew D, Cawston, Tim E, Young, David A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779431/
https://www.ncbi.nlm.nih.gov/pubmed/16919164
http://dx.doi.org/10.1186/ar2034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779431/
https://www.ncbi.nlm.nih.gov/pubmed/16919164
http://dx.doi.org/10.1186/ar2034

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