Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi

Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?

Detalles Bibliográficos
Autores principales: Snøve, Ola, Rossi, John J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779583/
https://www.ncbi.nlm.nih.gov/pubmed/16942630
http://dx.doi.org/10.1186/gb-2006-7-8-231

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779583/
https://www.ncbi.nlm.nih.gov/pubmed/16942630
http://dx.doi.org/10.1186/gb-2006-7-8-231

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