Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi

Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?

Detalles Bibliográficos
Autores principales: Snøve, Ola, Rossi, John J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779583/
https://www.ncbi.nlm.nih.gov/pubmed/16942630
http://dx.doi.org/10.1186/gb-2006-7-8-231
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author Snøve, Ola
Rossi, John J
author_facet Snøve, Ola
Rossi, John J
author_sort Snøve, Ola
collection PubMed
description Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?
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spelling pubmed-17795832007-01-19 Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi Snøve, Ola Rossi, John J Genome Biol Minireview Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins? BioMed Central 2006 2006-08-29 /pmc/articles/PMC1779583/ /pubmed/16942630 http://dx.doi.org/10.1186/gb-2006-7-8-231 Text en Copyright © 2006 BioMed Central Ltd
spellingShingle Minireview
Snøve, Ola
Rossi, John J
Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title_full Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title_fullStr Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title_full_unstemmed Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title_short Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
title_sort toxicity in mice expressing short hairpin rnas gives new insight into rnai
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779583/
https://www.ncbi.nlm.nih.gov/pubmed/16942630
http://dx.doi.org/10.1186/gb-2006-7-8-231
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