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Toxicity in mice expressing short hairpin RNAs gives new insight into RNAi
Short hairpin RNAs can provide stable gene silencing via RNA interference. Recent studies have shown toxicity in vivo that appears to be related to saturation of the endogenous microRNA pathway. Will these findings limit the therapeutic use of such hairpins?
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779583/ https://www.ncbi.nlm.nih.gov/pubmed/16942630 http://dx.doi.org/10.1186/gb-2006-7-8-231 |