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Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution

BACKGROUND: Systematic analyses of loss-of-function phenotypes have been carried out for most genes in Saccharomyces cerevisiae, Caenorhabditis elegans, and Drosophila melanogaster. Although such studies vastly expand our knowledge of single gene function, they do not address redundancy in genetic n...

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Detalles Bibliográficos
Autores principales: Tischler, Julia, Lehner, Ben, Chen, Nansheng, Fraser, Andrew G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779603/
https://www.ncbi.nlm.nih.gov/pubmed/16884526
http://dx.doi.org/10.1186/gb-2006-7-8-r69