The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.

Using the rat beta-cell RIN-5AH insulinoma line as a means for studying insulin-dependent diabetes mellitus (IDDM), it is shown that interleukin-1 (IL-1) induces beta-cell damage initiated by early apoptotic signals. This action is demonstrated by DNA fragmentation, as assessed by specific BrdU labe...

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Detalles Bibliográficos
Autores principales: Vassiliadis, S, Dragiotis, V, Protopapadakis, E, Athanassakis, I, Mitlianga, P, Konidaris, K, Papadopoulos, G K
Formato: Texto
Lenguaje:English
Publicado: 1999
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781784/
https://www.ncbi.nlm.nih.gov/pubmed/10704145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781784/
https://www.ncbi.nlm.nih.gov/pubmed/10704145

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