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The destructive action of IL-1alpha and IL-1beta in IDDM is a multistage process: evidence and confirmation by apoptotic studies, induction of intermediates and electron microscopy.
Using the rat beta-cell RIN-5AH insulinoma line as a means for studying insulin-dependent diabetes mellitus (IDDM), it is shown that interleukin-1 (IL-1) induces beta-cell damage initiated by early apoptotic signals. This action is demonstrated by DNA fragmentation, as assessed by specific BrdU labe...
Autores principales: | Vassiliadis, S, Dragiotis, V, Protopapadakis, E, Athanassakis, I, Mitlianga, P, Konidaris, K, Papadopoulos, G K |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
1999
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781784/ https://www.ncbi.nlm.nih.gov/pubmed/10704145 |
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