Cargando…
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7
BACKGROUND: The disabling chronic pain syndrome erythromelalgia (also termed erythermalgia) is characterized by attacks of burning pain in the extremities induced by warmth. Pharmacological treatment is often ineffective, but the pain can be alleviated by cooling of the limbs. Inherited erythromelal...
Autores principales: | Han, Chongyang, Lampert, Angelika, Rush, Anthony M, Dib-Hajj, Sulayman D, Wang, Xiaoliang, Yang, Yong, Waxman, Stephen G |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781932/ https://www.ncbi.nlm.nih.gov/pubmed/17239250 http://dx.doi.org/10.1186/1744-8069-3-3 |
Ejemplares similares
-
Mutation I136V alters electrophysiological properties of the Na(V)1.7 channel in a family with onset of erythromelalgia in the second decade
por: Cheng, Xiaoyang, et al.
Publicado: (2008) -
Network topology of NaV1.7 mutations in sodium channel-related painful disorders
por: Kapetis, Dimos, et al.
Publicado: (2017) -
Nonmuscle myosin II isoforms interact with sodium channel alpha subunits
por: Dash, Bhagirathi, et al.
Publicado: (2018) -
Mexiletine as a treatment for primary erythromelalgia: normalization of biophysical properties of mutant L858F Na(V)1.7 sodium channels
por: Cregg, R, et al.
Publicado: (2014) -
Fibroblast growth factor homologous factor 2 (FGF-13) associates with Nav1.7 in DRG neurons and alters its current properties in an isoform-dependent manner
por: Effraim, Philip R., et al.
Publicado: (2019)