Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus

BACKGROUND: IL-10 has a potent inhibitory effect on osteoclastogenesis. In vitro and in vivo studies confirm the importance of this cytokine in bone metabolism, for instance IL-10-deficient mice develop the hallmarks of osteoporosis. Although it is known that IL-10 directly inhibits osteoclastogenes...

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Detalles Bibliográficos
Autores principales: Evans, Kathryn E, Fox, Simon W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781937/
https://www.ncbi.nlm.nih.gov/pubmed/17239241
http://dx.doi.org/10.1186/1471-2121-8-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781937/
https://www.ncbi.nlm.nih.gov/pubmed/17239241
http://dx.doi.org/10.1186/1471-2121-8-4

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