Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the broad-based inhibitor TL-3, which inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Heaslet, Holly, Lin, Ying-Chuan, Tam, Karen, Torbett, Bruce E, Elder, John H, Stout, C David
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781954/
https://www.ncbi.nlm.nih.gov/pubmed/17212810
http://dx.doi.org/10.1186/1742-4690-4-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1781954/
https://www.ncbi.nlm.nih.gov/pubmed/17212810
http://dx.doi.org/10.1186/1742-4690-4-1

Ejemplares similares