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An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans

Human, animal, and in vitro research indicates a beneficial effect of appropriate amounts of omega-3 (n-3) polyunsaturated fatty acids (PUFA) on bone health. This is the first controlled feeding study in humans to evaluate the effect of dietary plant-derived n-3 PUFA on bone turnover, assessed by se...

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Autores principales: Griel, Amy E, Kris-Etherton, Penny M, Hilpert, Kirsten F, Zhao, Guixiang, West, Sheila G, Corwin, Rebecca L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784104/
https://www.ncbi.nlm.nih.gov/pubmed/17227589
http://dx.doi.org/10.1186/1475-2891-6-2
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author Griel, Amy E
Kris-Etherton, Penny M
Hilpert, Kirsten F
Zhao, Guixiang
West, Sheila G
Corwin, Rebecca L
author_facet Griel, Amy E
Kris-Etherton, Penny M
Hilpert, Kirsten F
Zhao, Guixiang
West, Sheila G
Corwin, Rebecca L
author_sort Griel, Amy E
collection PubMed
description Human, animal, and in vitro research indicates a beneficial effect of appropriate amounts of omega-3 (n-3) polyunsaturated fatty acids (PUFA) on bone health. This is the first controlled feeding study in humans to evaluate the effect of dietary plant-derived n-3 PUFA on bone turnover, assessed by serum concentrations of N-telopeptides (NTx) and bone-specific alkaline phosphatase (BSAP). Subjects (n = 23) consumed each diet for 6 weeks in a randomized, 3-period crossover design: 1) Average American Diet (AAD; [34% total fat, 13% saturated fatty acids (SFA), 13% monounsaturated fatty acids (MUFA), 9% PUFA (7.7% LA, 0.8% ALA)]), 2) Linoleic Acid Diet (LA; [37% total fat, 9% SFA, 12% MUFA, 16% PUFA (12.6% LA, 3.6% ALA)]), and 3) α-Linolenic Acid Diet (ALA; [38% total fat, 8% SFA, 12% MUFA, 17% PUFA (10.5% LA, 6.5% ALA)]). Walnuts and flaxseed oil were the predominant sources of ALA. NTx levels were significantly lower following the ALA diet (13.20 ± 1.21 nM BCE), relative to the AAD (15.59 ± 1.21 nM BCE) (p < 0.05). Mean NTx level following the LA diet was 13.80 ± 1.21 nM BCE. There was no change in levels of BSAP across the three diets. Concentrations of NTx were positively correlated with the pro-inflammatory cytokine TNFα for all three diets. The results indicate that plant sources of dietary n-3 PUFA may have a protective effect on bone metabolism via a decrease in bone resorption in the presence of consistent levels of bone formation.
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spelling pubmed-17841042007-01-31 An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans Griel, Amy E Kris-Etherton, Penny M Hilpert, Kirsten F Zhao, Guixiang West, Sheila G Corwin, Rebecca L Nutr J Research Human, animal, and in vitro research indicates a beneficial effect of appropriate amounts of omega-3 (n-3) polyunsaturated fatty acids (PUFA) on bone health. This is the first controlled feeding study in humans to evaluate the effect of dietary plant-derived n-3 PUFA on bone turnover, assessed by serum concentrations of N-telopeptides (NTx) and bone-specific alkaline phosphatase (BSAP). Subjects (n = 23) consumed each diet for 6 weeks in a randomized, 3-period crossover design: 1) Average American Diet (AAD; [34% total fat, 13% saturated fatty acids (SFA), 13% monounsaturated fatty acids (MUFA), 9% PUFA (7.7% LA, 0.8% ALA)]), 2) Linoleic Acid Diet (LA; [37% total fat, 9% SFA, 12% MUFA, 16% PUFA (12.6% LA, 3.6% ALA)]), and 3) α-Linolenic Acid Diet (ALA; [38% total fat, 8% SFA, 12% MUFA, 17% PUFA (10.5% LA, 6.5% ALA)]). Walnuts and flaxseed oil were the predominant sources of ALA. NTx levels were significantly lower following the ALA diet (13.20 ± 1.21 nM BCE), relative to the AAD (15.59 ± 1.21 nM BCE) (p < 0.05). Mean NTx level following the LA diet was 13.80 ± 1.21 nM BCE. There was no change in levels of BSAP across the three diets. Concentrations of NTx were positively correlated with the pro-inflammatory cytokine TNFα for all three diets. The results indicate that plant sources of dietary n-3 PUFA may have a protective effect on bone metabolism via a decrease in bone resorption in the presence of consistent levels of bone formation. BioMed Central 2007-01-16 /pmc/articles/PMC1784104/ /pubmed/17227589 http://dx.doi.org/10.1186/1475-2891-6-2 Text en Copyright © 2007 Griel et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Griel, Amy E
Kris-Etherton, Penny M
Hilpert, Kirsten F
Zhao, Guixiang
West, Sheila G
Corwin, Rebecca L
An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title_full An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title_fullStr An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title_full_unstemmed An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title_short An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
title_sort increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1784104/
https://www.ncbi.nlm.nih.gov/pubmed/17227589
http://dx.doi.org/10.1186/1475-2891-6-2
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