Exploitation of Other Social Amoebae by Dictyostelium caveatum

Dictyostelium amoebae faced with starvation trigger a developmental program during which many cells aggregate and form fruiting bodies that consist of a ball of spores held aloft by a thin stalk. This developmental strategy is open to several forms of exploitation, including the remarkable case of D...

Descripción completa

Detalles Bibliográficos
Autores principales: Nizak, Clément, Fitzhenry, Robert J., Kessin, Richard H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790701/
https://www.ncbi.nlm.nih.gov/pubmed/17299592
http://dx.doi.org/10.1371/journal.pone.0000212
_version_ 1782132122341867520
author Nizak, Clément
Fitzhenry, Robert J.
Kessin, Richard H.
author_facet Nizak, Clément
Fitzhenry, Robert J.
Kessin, Richard H.
author_sort Nizak, Clément
collection PubMed
description Dictyostelium amoebae faced with starvation trigger a developmental program during which many cells aggregate and form fruiting bodies that consist of a ball of spores held aloft by a thin stalk. This developmental strategy is open to several forms of exploitation, including the remarkable case of Dictyostelium caveatum, which, even when it constitutes 1/10(3) of the cells in an aggregate, can inhibit the development of the host and eventually devour it. We show that it accomplishes this feat by inhibiting a region of cells, called the tip, which organizes the development of the aggregate into a fruiting body. We use live-cell microscopy to define the D. caveatum developmental cycle and to show that D. caveatum amoebae have the capacity to ingest amoebae of other Dictyostelid species, but do not attack each other. The block in development induced by D. caveatum does not affect the expression of specific markers of prespore cell or prestalk cell differentiation, but does stop the coordinated cell movement leading to tip formation. The inhibition mechanism involves the constitutive secretion of a small molecule by D. caveatum and is reversible. Four Dictyostelid species were inhibited in their development, while D. caveatum is not inhibited by its own compound(s). D. caveatum has evolved a predation strategy to exploit other members of its genus, including mechanisms of developmental inhibition and specific phagocytosis.
format Text
id pubmed-1790701
institution National Center for Biotechnology Information
language English
publishDate 2007
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-17907012007-02-14 Exploitation of Other Social Amoebae by Dictyostelium caveatum Nizak, Clément Fitzhenry, Robert J. Kessin, Richard H. PLoS One Research Article Dictyostelium amoebae faced with starvation trigger a developmental program during which many cells aggregate and form fruiting bodies that consist of a ball of spores held aloft by a thin stalk. This developmental strategy is open to several forms of exploitation, including the remarkable case of Dictyostelium caveatum, which, even when it constitutes 1/10(3) of the cells in an aggregate, can inhibit the development of the host and eventually devour it. We show that it accomplishes this feat by inhibiting a region of cells, called the tip, which organizes the development of the aggregate into a fruiting body. We use live-cell microscopy to define the D. caveatum developmental cycle and to show that D. caveatum amoebae have the capacity to ingest amoebae of other Dictyostelid species, but do not attack each other. The block in development induced by D. caveatum does not affect the expression of specific markers of prespore cell or prestalk cell differentiation, but does stop the coordinated cell movement leading to tip formation. The inhibition mechanism involves the constitutive secretion of a small molecule by D. caveatum and is reversible. Four Dictyostelid species were inhibited in their development, while D. caveatum is not inhibited by its own compound(s). D. caveatum has evolved a predation strategy to exploit other members of its genus, including mechanisms of developmental inhibition and specific phagocytosis. Public Library of Science 2007-02-14 /pmc/articles/PMC1790701/ /pubmed/17299592 http://dx.doi.org/10.1371/journal.pone.0000212 Text en Nizak et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Nizak, Clément
Fitzhenry, Robert J.
Kessin, Richard H.
Exploitation of Other Social Amoebae by Dictyostelium caveatum
title Exploitation of Other Social Amoebae by Dictyostelium caveatum
title_full Exploitation of Other Social Amoebae by Dictyostelium caveatum
title_fullStr Exploitation of Other Social Amoebae by Dictyostelium caveatum
title_full_unstemmed Exploitation of Other Social Amoebae by Dictyostelium caveatum
title_short Exploitation of Other Social Amoebae by Dictyostelium caveatum
title_sort exploitation of other social amoebae by dictyostelium caveatum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790701/
https://www.ncbi.nlm.nih.gov/pubmed/17299592
http://dx.doi.org/10.1371/journal.pone.0000212
work_keys_str_mv AT nizakclement exploitationofothersocialamoebaebydictyosteliumcaveatum
AT fitzhenryrobertj exploitationofothersocialamoebaebydictyosteliumcaveatum
AT kessinrichardh exploitationofothersocialamoebaebydictyosteliumcaveatum