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SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

Cyclin D1 is an allosteric regulator for cyclin-dependent kinases 4 and 6 (CDK4/6). The cyclin D/CDK4 kinase promotes G1/S transition through the posttranslational modification and the subsequent inactivation of the retinoblastoma (Rb) protein and related family members (p107 and p130). Accumulation...

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Detalles Bibliográficos
Autores principales:	Barbash, Olena, Lin, Douglas I, Diehl, J Alan
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790704/ https://www.ncbi.nlm.nih.gov/pubmed/17224055 http://dx.doi.org/10.1186/1747-1028-2-2

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