Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli

Macrolide antibiotics such as erythromycin are clinically important polyketide natural products. We have engineered a recombinant strain of Escherichia coli that produces small but measurable quantities of the bioactive macrolide 6-deoxyerythromycin D. Bioassay-guided evolution of this strain led to...

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Detalles Bibliográficos
Autores principales: Lee, Ho Young, Khosla, Chaitan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790958/
https://www.ncbi.nlm.nih.gov/pubmed/17298179
http://dx.doi.org/10.1371/journal.pbio.0050045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790958/
https://www.ncbi.nlm.nih.gov/pubmed/17298179
http://dx.doi.org/10.1371/journal.pbio.0050045

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