Cargando…
Bioassay-Guided Evolution of Glycosylated Macrolide Antibiotics in Escherichia coli
Macrolide antibiotics such as erythromycin are clinically important polyketide natural products. We have engineered a recombinant strain of Escherichia coli that produces small but measurable quantities of the bioactive macrolide 6-deoxyerythromycin D. Bioassay-guided evolution of this strain led to...
| Autores principales: | , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1790958/ https://www.ncbi.nlm.nih.gov/pubmed/17298179 http://dx.doi.org/10.1371/journal.pbio.0050045 |