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Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions
Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU i...
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794076/ https://www.ncbi.nlm.nih.gov/pubmed/17497002 http://dx.doi.org/10.1155/BCA/2006/23214 |
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author | Roy, Gouriprasanna Mugesh, G. |
author_facet | Roy, Gouriprasanna Mugesh, G. |
author_sort | Roy, Gouriprasanna |
collection | PubMed |
description | Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)-catalyzed oxidation and iodination reactions by antithyroid drugs are described. |
format | Text |
id | pubmed-1794076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-17940762007-02-12 Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions Roy, Gouriprasanna Mugesh, G. Bioinorg Chem Appl Research Article Propylthiouracil (PTU) and methimazole (MMI) are the most commonly used antithyroid drugs. The available data suggest that these drugs may block the thyroid hormone synthesis by inhibiting the thyroid peroxidase (TPO) or diverting oxidized iodides away from thyroglobulin. It is also known that PTU inhibits the selenocysteine-containing enzyme ID-1 by reacting with the selenenyl iodide intermediate (E-SeI). In view of the current interest in antithyroid drugs, we have recently carried out biomimetic studies to understand the mechanism by which the antithyroid drugs inhibit the thyroid hormone synthesis and found that the replacement of sulfur with selenium in MMI leads to an interesting compound that may reversibly block the thyroid hormone synthesis. Our recent results on the inhibition of lactoperoxidase (LPO)-catalyzed oxidation and iodination reactions by antithyroid drugs are described. Hindawi Publishing Corporation 2006 2006-11-12 /pmc/articles/PMC1794076/ /pubmed/17497002 http://dx.doi.org/10.1155/BCA/2006/23214 Text en Copyright © 2006 G. Roy and G. Mugesh. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Roy, Gouriprasanna Mugesh, G. Bioinorganic Chemistry in Thyroid Gland: Effect of Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title | Bioinorganic Chemistry in Thyroid Gland: Effect of
Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title_full | Bioinorganic Chemistry in Thyroid Gland: Effect of
Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title_fullStr | Bioinorganic Chemistry in Thyroid Gland: Effect of
Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title_full_unstemmed | Bioinorganic Chemistry in Thyroid Gland: Effect of
Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title_short | Bioinorganic Chemistry in Thyroid Gland: Effect of
Antithyroid Drugs on Peroxidase-Catalyzed Oxidation and Iodination Reactions |
title_sort | bioinorganic chemistry in thyroid gland: effect of
antithyroid drugs on peroxidase-catalyzed oxidation and iodination reactions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794076/ https://www.ncbi.nlm.nih.gov/pubmed/17497002 http://dx.doi.org/10.1155/BCA/2006/23214 |
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