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Knockout Mice: Is It Just Genetics? Effect of Enriched Housing on Fibulin-4(+/−) Mice
BACKGROUND: Fibulin-4 is an extracellular matrix protein expressed by vascular smooth muscle cells that is essential for maintaining arterial integrity. Fibulin-4(−/−) mice die just before birth due to arterial hemorrhage, but fibulin-4(+/−) mice appear to be outwardly normal. Experiments were there...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794134/ https://www.ncbi.nlm.nih.gov/pubmed/17311093 http://dx.doi.org/10.1371/journal.pone.0000229 |