PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is defic...

Descripción completa

Detalles Bibliográficos
Autores principales: You, Xin, Boyle, David L, Hammaker, Deepa, Firestein, Gary S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794498/
https://www.ncbi.nlm.nih.gov/pubmed/17014719
http://dx.doi.org/10.1186/ar2052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794498/
https://www.ncbi.nlm.nih.gov/pubmed/17014719
http://dx.doi.org/10.1186/ar2052

Ejemplares similares