PUMA-mediated apoptosis in fibroblast-like synoviocytes does not require p53

PUMA (p53-upregulated modulator of apoptosis) is a pro-apoptotic gene that can induce rapid cell death through a p53-dependent mechanism. However, the efficacy of PUMA gene therapy to induce synovial apoptosis in rheumatoid arthritis might have limited efficacy if p53 expression or function is defic...

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Detalles Bibliográficos
Autores principales: You, Xin, Boyle, David L, Hammaker, Deepa, Firestein, Gary S
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794498/
https://www.ncbi.nlm.nih.gov/pubmed/17014719
http://dx.doi.org/10.1186/ar2052

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