The proinflammatory cytokines IL-1β and TNF-α induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway

The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis (RA). The expression of Synoviolin (SYN), an E3 ubiquitin ligase, is upregulated in arthritic synovial fibroblasts and is involved in the overgrowth of synovial cells during RA. However, the molecular mechanis...

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Detalles Bibliográficos
Autores principales: Gao, Beixue, Calhoun, Karen, Fang, Deyu
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794516/
https://www.ncbi.nlm.nih.gov/pubmed/17105652
http://dx.doi.org/10.1186/ar2081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794516/
https://www.ncbi.nlm.nih.gov/pubmed/17105652
http://dx.doi.org/10.1186/ar2081

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