Retroviral activation of the mir-106a microRNA cistron in T lymphoma

Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron....

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Autores principales: Lum, Amy M, Wang, Bruce B, Li, Lauri, Channa, Namitha, Bartha, Gabor, Wabl, Matthias
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794537/
https://www.ncbi.nlm.nih.gov/pubmed/17442096
http://dx.doi.org/10.1186/1742-4690-4-5
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author Lum, Amy M
Wang, Bruce B
Li, Lauri
Channa, Namitha
Bartha, Gabor
Wabl, Matthias
author_facet Lum, Amy M
Wang, Bruce B
Li, Lauri
Channa, Namitha
Bartha, Gabor
Wabl, Matthias
author_sort Lum, Amy M
collection PubMed
description Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis.
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spelling pubmed-17945372007-02-08 Retroviral activation of the mir-106a microRNA cistron in T lymphoma Lum, Amy M Wang, Bruce B Li, Lauri Channa, Namitha Bartha, Gabor Wabl, Matthias Retrovirology Short Report Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis. BioMed Central 2007-01-25 /pmc/articles/PMC1794537/ /pubmed/17442096 http://dx.doi.org/10.1186/1742-4690-4-5 Text en Copyright © 2007 Lum et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Lum, Amy M
Wang, Bruce B
Li, Lauri
Channa, Namitha
Bartha, Gabor
Wabl, Matthias
Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_full Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_fullStr Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_full_unstemmed Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_short Retroviral activation of the mir-106a microRNA cistron in T lymphoma
title_sort retroviral activation of the mir-106a microrna cistron in t lymphoma
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794537/
https://www.ncbi.nlm.nih.gov/pubmed/17442096
http://dx.doi.org/10.1186/1742-4690-4-5
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