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A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression
A Melanesian variant of the genetic disease α-thalassemia has recently been shown to be due to a single-nucleotide polymorphism located between the adult α-globin genes and their enhancers. The finding that this mutation creates a novel promoter provides support for a mechanism of gene regulation by...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794567/ https://www.ncbi.nlm.nih.gov/pubmed/17076879 http://dx.doi.org/10.1186/gb-2006-7-10-238 |