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A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression
A Melanesian variant of the genetic disease α-thalassemia has recently been shown to be due to a single-nucleotide polymorphism located between the adult α-globin genes and their enhancers. The finding that this mutation creates a novel promoter provides support for a mechanism of gene regulation by...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2006
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794567/ https://www.ncbi.nlm.nih.gov/pubmed/17076879 http://dx.doi.org/10.1186/gb-2006-7-10-238 |
| _version_ | 1782132213058371584 |
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| author | Li, Qiliang |
| author_facet | Li, Qiliang |
| author_sort | Li, Qiliang |
| collection | PubMed |
| description | A Melanesian variant of the genetic disease α-thalassemia has recently been shown to be due to a single-nucleotide polymorphism located between the adult α-globin genes and their enhancers. The finding that this mutation creates a novel promoter provides support for a mechanism of gene regulation by facilitated chromatin looping. |
| format | Text |
| id | pubmed-1794567 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2006 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-17945672007-02-08 A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression Li, Qiliang Genome Biol Minireview A Melanesian variant of the genetic disease α-thalassemia has recently been shown to be due to a single-nucleotide polymorphism located between the adult α-globin genes and their enhancers. The finding that this mutation creates a novel promoter provides support for a mechanism of gene regulation by facilitated chromatin looping. BioMed Central 2006 2006-10-24 /pmc/articles/PMC1794567/ /pubmed/17076879 http://dx.doi.org/10.1186/gb-2006-7-10-238 Text en Copyright © 2006 BioMed Central Ltd |
| spellingShingle | Minireview Li, Qiliang A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title | A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title_full | A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title_fullStr | A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title_full_unstemmed | A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title_short | A Melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| title_sort | melanesian α-thalassemia mutation suggests a novel mechanism for regulating gene expression |
| topic | Minireview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794567/ https://www.ncbi.nlm.nih.gov/pubmed/17076879 http://dx.doi.org/10.1186/gb-2006-7-10-238 |
| work_keys_str_mv | AT liqiliang amelanesianathalassemiamutationsuggestsanovelmechanismforregulatinggeneexpression AT liqiliang melanesianathalassemiamutationsuggestsanovelmechanismforregulatinggeneexpression |