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How complete are current yeast and human protein-interaction networks?

We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data m...

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Detalles Bibliográficos
Autores principales: Hart, G Traver, Ramani, Arun K, Marcotte, Edward M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794583/
https://www.ncbi.nlm.nih.gov/pubmed/17147767
http://dx.doi.org/10.1186/gb-2006-7-11-120
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author Hart, G Traver
Ramani, Arun K
Marcotte, Edward M
author_facet Hart, G Traver
Ramani, Arun K
Marcotte, Edward M
author_sort Hart, G Traver
collection PubMed
description We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
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spelling pubmed-17945832007-02-08 How complete are current yeast and human protein-interaction networks? Hart, G Traver Ramani, Arun K Marcotte, Edward M Genome Biol Opinion We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions. BioMed Central 2006 2006-12-01 /pmc/articles/PMC1794583/ /pubmed/17147767 http://dx.doi.org/10.1186/gb-2006-7-11-120 Text en Copyright © 2006 BioMed Central Ltd
spellingShingle Opinion
Hart, G Traver
Ramani, Arun K
Marcotte, Edward M
How complete are current yeast and human protein-interaction networks?
title How complete are current yeast and human protein-interaction networks?
title_full How complete are current yeast and human protein-interaction networks?
title_fullStr How complete are current yeast and human protein-interaction networks?
title_full_unstemmed How complete are current yeast and human protein-interaction networks?
title_short How complete are current yeast and human protein-interaction networks?
title_sort how complete are current yeast and human protein-interaction networks?
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794583/
https://www.ncbi.nlm.nih.gov/pubmed/17147767
http://dx.doi.org/10.1186/gb-2006-7-11-120
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