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How complete are current yeast and human protein-interaction networks?
We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data m...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794583/ https://www.ncbi.nlm.nih.gov/pubmed/17147767 http://dx.doi.org/10.1186/gb-2006-7-11-120 |
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author | Hart, G Traver Ramani, Arun K Marcotte, Edward M |
author_facet | Hart, G Traver Ramani, Arun K Marcotte, Edward M |
author_sort | Hart, G Traver |
collection | PubMed |
description | We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions. |
format | Text |
id | pubmed-1794583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-17945832007-02-08 How complete are current yeast and human protein-interaction networks? Hart, G Traver Ramani, Arun K Marcotte, Edward M Genome Biol Opinion We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions. BioMed Central 2006 2006-12-01 /pmc/articles/PMC1794583/ /pubmed/17147767 http://dx.doi.org/10.1186/gb-2006-7-11-120 Text en Copyright © 2006 BioMed Central Ltd |
spellingShingle | Opinion Hart, G Traver Ramani, Arun K Marcotte, Edward M How complete are current yeast and human protein-interaction networks? |
title | How complete are current yeast and human protein-interaction networks? |
title_full | How complete are current yeast and human protein-interaction networks? |
title_fullStr | How complete are current yeast and human protein-interaction networks? |
title_full_unstemmed | How complete are current yeast and human protein-interaction networks? |
title_short | How complete are current yeast and human protein-interaction networks? |
title_sort | how complete are current yeast and human protein-interaction networks? |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794583/ https://www.ncbi.nlm.nih.gov/pubmed/17147767 http://dx.doi.org/10.1186/gb-2006-7-11-120 |
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