The Role of Citrullinated Proteins Suggests a Novel Mechanism in the Pathogenesis of Multiple Sclerosis

The pathogenesis of MS is unknown. In our studies, we have demonstrated an important role for citrullinated myelin basic protein (MBP). The accompanying loss of positive charge compromises the ability of MBP to interact with the lipid bilayer. The conversion of arginine to citrulline in brain is car...

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Detalles Bibliográficos
Autores principales: Moscarello, Mario A., Mastronardi, Fabrizio G., Wood, D. Denise
Formato: Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers-Plenum Publishers 2006
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794624/
https://www.ncbi.nlm.nih.gov/pubmed/17031564
http://dx.doi.org/10.1007/s11064-006-9144-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794624/
https://www.ncbi.nlm.nih.gov/pubmed/17031564
http://dx.doi.org/10.1007/s11064-006-9144-5

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