Cargando…

Depletion of ceramides with very long chain fatty acids causes defective skin permeability barrier function, and neonatal lethality in ELOVL4 deficient mice

Very long chain fatty acids (VLCFA), either free or as components of glycerolipids and sphingolipids, are present in many organs. Elongation of very long chain fatty acids-4 (ELOVL4) belongs to a family of 6 members of putative fatty acid elongases that are involved in the formation of VLCFA. Mutati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wenmei, Sandhoff, Roger, Kono, Mari, Zerfas, Patricia, Hoffmann, Vickie, Ding, Bryan Char-Hoa, Proia, Richard L., Deng, Chu-Xia
Formato:	Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2007
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796950/ https://www.ncbi.nlm.nih.gov/pubmed/17311087

Ejemplares similares

Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival
por: Cameron, D. Joshua, et al.
Publicado: (2007)

The role of ELOVL1 in very long-chain fatty acid homeostasis and X-linked adrenoleukodystrophy
por: Ofman, Rob, et al.
Publicado: (2010)

ELOVL4: Very long-chain fatty acids serve an eclectic role in mammalian health and function
por: Hopiavuori, Blake R., et al.
Publicado: (2018)

Novel Cellular Functions of Very Long Chain-Fatty Acids: Insight From ELOVL4 Mutations
por: Deák, Ferenc, et al.
Publicado: (2019)

Long-Chain and Very Long-Chain Ceramides Mediate Doxorubicin-Induced Toxicity and Fibrosis
por: Kretzschmar, Tom, et al.
Publicado: (2021)

Very long chain fatty acid-containing lipids: a decade of novel insights from the study of ELOVL4
por: Yeboah, Gyening Kofi, et al.
Publicado: (2021)

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis
por: Gyening, Yeboah Kofi, et al.
Publicado: (2022)

Glioblastoma Multiforme Tumors in Women Have a Lower Expression of Fatty Acid Elongases ELOVL2, ELOVL5, ELOVL6, and ELOVL7 than in Men
por: Korbecki, Jan, et al.
Publicado: (2022)

Role of Intracellular Lipid Logistics in the Preferential Usage of Very Long Chain-Ceramides in Glucosylceramide
por: Yamaji, Toshiyuki, et al.
Publicado: (2016)

Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency
por: Hopiavuori, Blake R., et al.
Publicado: (2017)

Elongation of very Long-Chain (>C(24)) Fatty Acids in Clarias gariepinus: Cloning, Functional Characterization and Tissue Expression of elovl4 Elongases
por: Oboh, Angela, et al.
Publicado: (2017)

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
por: Sentelle, R. David, et al.
Publicado: (2012)

Differences in plasma levels of long chain and very long chain ceramides between African Americans and whites: An observational study
por: Buie, Joy N. Jones, et al.
Publicado: (2019)

Blood-brain barrier permeability analysis of plant ceramides
por: Eguchi, Koichi, et al.
Publicado: (2020)

Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma
por: Wang, Zheng, et al.
Publicado: (2017)

Therapeutic Role of ELOVL in Neurological Diseases
por: Siddiqui, Arif Jamal, et al.
Publicado: (2023)

Genetic Architecture of Circulating Very-Long-Chain (C24:0 and C22:0) Ceramide Concentrations
por: Cresci, Sharon, et al.
Publicado: (2020)

Long and Very-Long-Chain Ceramides Correlate with A More Aggressive Behavior in Skull Base Chordoma Patients
por: La Corte, Emanuele, et al.
Publicado: (2019)

Remodeling of Retinal Fatty Acids in an Animal Model of Diabetes: A Decrease in Long-Chain Polyunsaturated Fatty Acids Is Associated With a Decrease in Fatty Acid Elongases Elovl2 and Elovl4
por: Tikhonenko, Maria, et al.
Publicado: (2010)

Dominant Elongase Activity of Elovl5a but Higher Expression of Elovl5b in Common Carp (Cyprinus carpio)
por: Zhao, Ran, et al.
Publicado: (2022)

Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides
por: Trayssac, Magali, et al.
Publicado: (2021)

Cloning and expression characterization of elongation of very long-chain fatty acids protein 6 (elovl6) with dietary fatty acids, ambient salinity and starvation stress in Scylla paramamosain
por: Lin, Zhideng, et al.
Publicado: (2023)

Effects of (R)- and (S)-α-Hydroxylation of Acyl Chains in Sphingosine, Dihydrosphingosine, and Phytosphingosine Ceramides on Phase Behavior and Permeability of Skin Lipid Models
por: Kováčik, Andrej, et al.
Publicado: (2021)

ELOVL5-Mediated Long Chain Fatty Acid Elongation Contributes to Enzalutamide Resistance of Prostate Cancer
por: Xu, Huan, et al.
Publicado: (2021)

ELOVL2: Not just a biomarker of aging
por: Chao, Daniel L., et al.
Publicado: (2020)

Unsaturation of Very-Long-Chain Ceramides Protects Plant from Hypoxia-Induced Damages by Modulating Ethylene Signaling in Arabidopsis
por: Xie, Li-Juan, et al.
Publicado: (2015)

The Sphingosine and Acyl Chains of Ceramide [NS] Show Very Different Structure and Dynamics That Challenge Our Understanding of the Skin Barrier
por: Engberg, Oskar, et al.
Publicado: (2020)

Long- and very long-chain ceramides are predictors of acute kidney injury in patients with acute coronary syndrome: the PEACP study
por: Liang, Lianjing, et al.
Publicado: (2023)

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression
por: Su, Yu-Chu, et al.
Publicado: (2018)

Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea)
por: Li, Songlin, et al.
Publicado: (2017)

Zymosan-Induced Murine Peritonitis Is Associated with an Increased Sphingolipid Synthesis without Changing the Long to Very Long Chain Ceramide Ratio
por: Pierron, Alix, et al.
Publicado: (2023)

Distribution of ELOVL4 in the Developing and Adult Mouse Brain
por: Sherry, David M., et al.
Publicado: (2017)

Elovl2 Is Required for Robust Visual Function in Zebrafish
por: Dasyani, Manish, et al.
Publicado: (2020)

Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl1
por: Isokawa, Masashi, et al.
Publicado: (2019)

Cooperative Synthesis of Ultra Long-Chain Fatty Acid and Ceramide during Keratinocyte Differentiation
por: Mizutani, Yukiko, et al.
Publicado: (2013)

Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine ceramides
por: Ota, Ai, et al.
Publicado: (2023)

Association Analysis between Genetic Variants of elovl5a and elovl5b and Poly-Unsaturated Fatty Acids in Common Carp (Cyprinus carpio)
por: Zhang, Yan, et al.
Publicado: (2022)

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6
por: Tan, Chong Yew, et al.
Publicado: (2015)

Elovl5 Expression in the Central Nervous System of the Adult Mouse
por: Balbo, Ilaria, et al.
Publicado: (2021)

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice
por: Wang, Xin, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_e9262kn1o75udbqudl0urta8g2