E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation

BACKGROUND: PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells. METHODS: PUMA gene and protein expression levels were detect...

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Detalles Bibliográficos
Autores principales: Hao, Hongying, Dong, Yanbin, Bowling, Maria T, Gomez-Gutierrez, Jorge G, Zhou, H Sam, McMasters, Kelly M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797184/
https://www.ncbi.nlm.nih.gov/pubmed/17263886
http://dx.doi.org/10.1186/1471-2407-7-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797184/
https://www.ncbi.nlm.nih.gov/pubmed/17263886
http://dx.doi.org/10.1186/1471-2407-7-24

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