Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair

BACKGROUND: Single-stranded oligonucleotides (ssODN) are used routinely to direct specific base alterations within mammalian genomes that result in the restoration of a functional gene. Despite success with the technique, recent studies have revealed that following repair events, correction frequenc...

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Detalles Bibliográficos
Autores principales: Engstrom, Julia U, Kmiec, Eric B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797188/
https://www.ncbi.nlm.nih.gov/pubmed/17284323
http://dx.doi.org/10.1186/1471-2199-8-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797188/
https://www.ncbi.nlm.nih.gov/pubmed/17284323
http://dx.doi.org/10.1186/1471-2199-8-9

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