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Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair
BACKGROUND: Single-stranded oligonucleotides (ssODN) are used routinely to direct specific base alterations within mammalian genomes that result in the restoration of a functional gene. Despite success with the technique, recent studies have revealed that following repair events, correction frequenc...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797188/ https://www.ncbi.nlm.nih.gov/pubmed/17284323 http://dx.doi.org/10.1186/1471-2199-8-9 |