Nonenzymatic Functions of Acetylcholinesterase Splice Variants in the Developmental Neurotoxicity of Organophosphates: Chlorpyrifos, Chlorpyrifos Oxon, and Diazinon

BACKGROUND: Organophosphate pesticides affect mammalian brain development through mechanisms separable from the inhibition of acetylcholinesterase (AChE) enzymatic activity and resultant cholinergic hyperstimulation. In the brain, AChE has two catalytically similar splice variants with distinct func...

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Detalles Bibliográficos
Autores principales: Jameson, Ruth R., Seidler, Frederic J., Slotkin, Theodore A.
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2007
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797835/
https://www.ncbi.nlm.nih.gov/pubmed/17366821
http://dx.doi.org/10.1289/ehp.9487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1797835/
https://www.ncbi.nlm.nih.gov/pubmed/17366821
http://dx.doi.org/10.1289/ehp.9487

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