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Distal hinge of plasminogen activator inhibitor-1 involves its latency transition and specificities toward serine proteases
BACKGROUND: The plasminogen activator inhibitor-1 (PAI-1) spontaneously converts from an inhibitory into a latent form. Specificity of PAI-1 is mainly determined by its reactive site (Arg346-Met347), which interacts with serine residue of tissue-type plasminogen activator (tPA) with concomitant form...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC179894/ https://www.ncbi.nlm.nih.gov/pubmed/12848892 http://dx.doi.org/10.1186/1471-2091-4-5 |