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Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Kinase 2
BACKGROUND: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure yet are mediated by only a few key residues. Transitional Dynamic Analysis (TDA) is a new method to detect these changes...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2007
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800904/ https://www.ncbi.nlm.nih.gov/pubmed/17286863 http://dx.doi.org/10.1186/1471-2105-8-45 |