Proteasome Activator Enhances Survival of Huntington's Disease Neuronal Model Cells

In patients with Huntington's disease (HD), the proteolytic activity of the ubiquitin proteasome system (UPS) is reduced in the brain and other tissues. The pathological hallmark of HD is the intraneuronal nuclear protein aggregates of mutant huntingtin. We determined how to enhance UPS functio...

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Detalles Bibliográficos
Autores principales: Seo, Hyemyung, Sonntag, Kai-Christian, Kim, Woori, Cattaneo, Elena, Isacson, Ole
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800909/
https://www.ncbi.nlm.nih.gov/pubmed/17327906
http://dx.doi.org/10.1371/journal.pone.0000238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800909/
https://www.ncbi.nlm.nih.gov/pubmed/17327906
http://dx.doi.org/10.1371/journal.pone.0000238

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