A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

BACKGROUND: Bone morphogenetic proteins (BMPs) are key regulators in the embryonic development and postnatal tissue homeostasis in all animals. Loss of function or dysregulation of BMPs results in severe diseases or even lethality. Like transforming growth factors β (TGF-βs), activins, growth and di...

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Detalles Bibliográficos
Autores principales: Weber, Dionys, Kotzsch, Alexander, Nickel, Joachim, Harth, Stefan, Seher, Axel, Mueller, Uwe, Sebald, Walter, Mueller, Thomas D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802081/
https://www.ncbi.nlm.nih.gov/pubmed/17295905
http://dx.doi.org/10.1186/1472-6807-7-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802081/
https://www.ncbi.nlm.nih.gov/pubmed/17295905
http://dx.doi.org/10.1186/1472-6807-7-6

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