Structural basis for activation of the therapeutic l-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase

l-nucleoside analogs represent an important class of small molecules for treating both viral infections and cancers. These pro-drugs achieve pharmacological activity only after enzyme-catalyzed conversion to their tri-phosphorylated forms. Herein, we report the crystal structures of human deoxycytid...

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Detalles Bibliográficos
Autores principales: Sabini, Elisabetta, Hazra, Saugata, Konrad, Manfred, Burley, Stephen K., Lavie, Arnon
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802566/
https://www.ncbi.nlm.nih.gov/pubmed/17158155
http://dx.doi.org/10.1093/nar/gkl1038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802566/
https://www.ncbi.nlm.nih.gov/pubmed/17158155
http://dx.doi.org/10.1093/nar/gkl1038

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