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The p16(INK4a) tumor suppressor controls p21(WAF1) induction in response to ultraviolet light
p16(INK4a) and p21(WAF1), two major cyclin-dependent kinase inhibitors, are the products of two tumor suppressor genes that play important roles in various cellular metabolic pathways. p21(WAF1) is up-regulated in response to different DNA damaging agents. While the activation of p21(WAF1) is p53-de...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802571/ https://www.ncbi.nlm.nih.gov/pubmed/17158160 http://dx.doi.org/10.1093/nar/gkl1075 |