Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis

Despite extensive study, the mechanism by which retroviral reverse transciptases (RTs) specifically utilize polypurine tract (PPT) RNA for initiation of plus-strand DNA synthesis remains unclear. Three sequence motifs within or adjacent to the purine-rich elements are highly conserved, namely, a rU:...

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Detalles Bibliográficos
Autores principales: Rausch, Jason W., Le Grice, Stuart F. J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802577/
https://www.ncbi.nlm.nih.gov/pubmed/17164285
http://dx.doi.org/10.1093/nar/gkl909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802577/
https://www.ncbi.nlm.nih.gov/pubmed/17164285
http://dx.doi.org/10.1093/nar/gkl909

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