Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes

Humans have two nearly identical copies of the survival motor neuron (SMN ) gene, SMN1 and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is unable to prevent the disease due to skipping of exon 7. Using a systematic approach of in vivo selection, we have previously demonst...

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Detalles Bibliográficos
Autores principales: Singh, Natalia N., Singh, Ravindra N., Androphy, Elliot J.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2007
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802598/
https://www.ncbi.nlm.nih.gov/pubmed/17170000
http://dx.doi.org/10.1093/nar/gkl1050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802598/
https://www.ncbi.nlm.nih.gov/pubmed/17170000
http://dx.doi.org/10.1093/nar/gkl1050

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