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Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
While methylcytosines serve as the fifth base encoding epigenetic information, they are also a dangerous endogenous mutagen due to their intrinsic instability. Methylcytosine undergoes spontaneous deamination, at a rate much higher than cytosine, to generate thymine. In mammals, two repair enzymes,...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2007
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802599/ https://www.ncbi.nlm.nih.gov/pubmed/17175537 http://dx.doi.org/10.1093/nar/gkl1052 |