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Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair

While methylcytosines serve as the fifth base encoding epigenetic information, they are also a dangerous endogenous mutagen due to their intrinsic instability. Methylcytosine undergoes spontaneous deamination, at a rate much higher than cytosine, to generate thymine. In mammals, two repair enzymes,...

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Detalles Bibliográficos
Autores principales:	Li, Ya-Qiang, Zhou, Ping-Zhu, Zheng, Xiu-Dan, Walsh, Colum P., Xu, Guo-Liang
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2007
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802599/ https://www.ncbi.nlm.nih.gov/pubmed/17175537 http://dx.doi.org/10.1093/nar/gkl1052

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